SOX21

SOX21
Identifiers
Aliases	SOX21, SOX25, SRY-box 21, SRY-box transcription factor 21
External IDs	OMIM: 604974; MGI: 2654070; HomoloGene: 5143; GeneCards: SOX21; OMA:SOX21 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	94,712,545 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	118,474,442 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; skin of leg; ; skin of abdomen; ; amygdala; ; caudate nucleus; ; mucosa of esophagus; ; putamen; ; nucleus accumbens; ; cingulate gyrus;
	Top expressed in
	saccule; ; hair follicle; ; molar; ; otic placode; ; otic vesicle; ; epithelium of stomach; ; ventricular zone; ; medial ganglionic eminence; ; pyloric antrum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cellular component;
Biological process	hair follicle development; regulation of transcription by RNA polymerase II; hair cycle; regulation of transcription, DNA-templated; transcription, DNA-templated; stem cell differentiation; skin development; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; cell differentiation; central nervous system development; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	11166
	223227
	ENSG00000125285
	ENSMUSG00000061517
	Q9Y651
	Q811W0
	NM_007084
	NM_177753
	NP_009015
	NP_808421
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.^[5]^[6] It is a member of the Sox gene family of transcription factors.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125285 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061517 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. S2CID 27862567.
^ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125285 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061517 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10441749-5] Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. S2CID 27862567.

[entrez-6] "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21".

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