SPA17

SPA17
Identifiers
Aliases	SPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17
External IDs	OMIM: 608621; MGI: 1333778; HomoloGene: 7951; GeneCards: SPA17; OMA:SPA17 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	124,697,518 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	37,525,018 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; sperm; ; left testis; ; right testis; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; right uterine tube; ; caput epididymis; ; Epithelium of choroid plexus; ; epithelium of nasopharynx;
	Top expressed in
	seminiferous tubule; ; spermatid; ; olfactory epithelium; ; spermatocyte; ; choroidal fissure; ; right kidney; ; lumbar spinal ganglion; ; right lung lobe; ; ventricular zone; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calmodulin binding;
Cellular component	cytoplasm; sperm principal piece; motile cilium; sperm fibrous sheath; external side of plasma membrane; membrane; cilium; extracellular region;
Biological process	epithelial cilium movement involved in extracellular fluid movement; spermatogenesis; single fertilization; binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	53340
	20686
	ENSG00000064199
	ENSMUSG00000001948
	Q15506
	Q62252
	NM_017425
	NM_011449; NM_001324545
	NP_059121
	NP_001311474; NP_035579
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.^[5]^[6]

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001948 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.
^ ^a ^b "Entrez Gene: SPA17 sperm autoantigenic protein 17".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001948 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8688458-5] Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.

[entrez-6] "Entrez Gene: SPA17 sperm autoantigenic protein 17".

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