SPIB

SPIB
Identifiers
Aliases	SPIB, SPI-B, Spi-B transcription factor
External IDs	OMIM: 606802; MGI: 892986; HomoloGene: 79220; GeneCards: SPIB; OMA:SPIB - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,431,314 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,181,495 bp
RNA expression pattern
	Top expressed in
	lymph node; ; mucosa of transverse colon; ; appendix; ; granulocyte; ; buccal mucosa cell; ; spleen; ; rectum; ; mucosa of ileum; ; epithelium of nasopharynx; ; blood;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; blood; ; granulocyte; ; subcutaneous adipose tissue; ; submandibular gland; ; bone marrow; ; thymus; ; femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6689
	272382
	ENSG00000269404
	ENSMUSG00000008193
	Q01892
	O35906
	NM_003121; NM_001243998; NM_001243999; NM_001244000
	NM_019866
	NP_001230927; NP_001230928; NP_001230929; NP_003112
	NP_063919
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000269404 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology. 12 (10): 4297–304. doi:10.1128/mcb.12.10.4297. PMC 360353. PMID 1406622.
^ "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000269404 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1406622-5] Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology. 12 (10): 4297–304. doi:10.1128/mcb.12.10.4297. PMC 360353. PMID 1406622.

[entrez-6] "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".

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