SPTLC2

SPTLC2
Identifiers
Aliases	SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a, serine palmitoyltransferase long chain base subunit 2
External IDs	OMIM: 605713; MGI: 108074; HomoloGene: 21610; GeneCards: SPTLC2; OMA:SPTLC2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	77,616,637 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	87,435,129 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; monocyte; ; subthalamic nucleus; ; C1 segment; ; stromal cell of endometrium; ; buccal mucosa cell; ; pars reticulata; ; blood;
	Top expressed in
	decidua; ; gastrula; ; genital tubercle; ; granulocyte; ; duodenum; ; tail of embryo; ; ileum; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; catalytic activity; serine C-palmitoyltransferase activity; pyridoxal phosphate binding; acyltransferase activity;
Cellular component	integral component of membrane; serine C-palmitoyltransferase complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; mitochondrion;
Biological process	lipid metabolism; sphinganine biosynthetic process; sphingosine biosynthetic process; sphingolipid biosynthetic process; biosynthesis; sphingomyelin biosynthetic process; positive regulation of lipophagy; metabolism; ceramide biosynthetic process; sphingolipid metabolic process; adipose tissue development;
	Sources:Amigo / QuickGO
Orthologs
	9517
	20773
	ENSG00000100596
	ENSMUSG00000021036
	O15270
	P97363
	NM_004863
	NM_011479
	NP_004854; NP_004854.1
	NP_035609
	Wikidata
View/Edit Human	View/Edit Mouse

Serine palmitoyltransferase, long chain base subunit 2, also known as SPTLC2, is a protein which in humans is encoded by the SPTLC2 gene.^[5]^[6]^[7] SPTLC2 belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100596 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021036 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2".
^ Nagiec MM, Lester RL, Dickson RC (October 1996). "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase". Gene. 177 (1–2): 237–241. doi:10.1016/0378-1119(96)00309-5. PMID 8921873.
^ Weiss B, Stoffel W (October 1997). "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis". European Journal of Biochemistry. 249 (1): 239–247. doi:10.1111/j.1432-1033.1997.00239.x. PMID 9363775.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100596 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021036 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2".

[pmid8921873-6] Nagiec MM, Lester RL, Dickson RC (October 1996). "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase". Gene. 177 (1–2): 237–241. doi:10.1016/0378-1119(96)00309-5. PMID 8921873.

[pmid9363775-7] Weiss B, Stoffel W (October 1997). "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis". European Journal of Biochemistry. 249 (1): 239–247. doi:10.1111/j.1432-1033.1997.00239.x. PMID 9363775.

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