STAT1

STAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WWT, 1BF5, 1YVL, 2KA6
Identifiers
Aliases	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
External IDs	OMIM: 600555; MGI: 103063; HomoloGene: 21428; GeneCards: STAT1; OMA:STAT1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.2 Start 190,908,460 bp[1] End 191,020,960 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.1|1 26.81 cM Start 52,158,599 bp[2] End 52,201,024 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx appendix mononuclear cell monocyte decidua endothelial cell lymph node glomerulus granulocyte metanephric glomerulus Top expressed in granulocyte thymus spleen mesenteric lymph nodes gastrula submandibular gland blood epithelium of lens subcutaneous adipose tissue mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity DNA-binding transcription factor activity RNA polymerase II general transcription initiation factor activity signal transducer activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding identical protein binding enzyme binding tumor necrosis factor receptor binding double-stranded DNA binding RNA polymerase II core promoter sequence-specific DNA binding cadherin binding histone acetyltransferase binding histone binding ubiquitin-like protein ligase binding promoter-specific chromatin binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding CCR5 chemokine receptor binding protein phosphatase 2A binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nucleoplasm nucleolus perinuclear region of cytoplasm nucleus cytosol axon dendrite protein-containing complex Biological process regulation of apoptotic process metanephric mesenchymal cell proliferation involved in metanephros development regulation of transcription, DNA-templated cellular response to interferon-beta regulation of transcription by RNA polymerase II negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric mesenchymal cell differentiation tumor necrosis factor-mediated signaling pathway negative regulation of transcription by RNA polymerase II renal tubule development response to interferon-beta negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated negative regulation of endothelial cell proliferation regulation of type I interferon-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway positive regulation of mesenchymal cell proliferation negative regulation of metanephric nephron tubule epithelial cell differentiation negative regulation of angiogenesis negative regulation by virus of viral protein levels in host cell viral process endothelial cell migration positive regulation of transcription by RNA polymerase II signal transduction macrophage derived foam cell differentiation positive regulation of erythrocyte differentiation type I interferon signaling pathway cellular response to interferon-gamma positive regulation of defense response to virus by host positive regulation of interferon-alpha production positive regulation of transcription, DNA-templated defense response to virus interferon-gamma-mediated signaling pathway receptor signaling pathway via JAK-STAT response to nutrient blood circulation positive regulation of cell population proliferation response to mechanical stimulus response to organic cyclic compound cellular response to insulin stimulus response to cytokine response to hydrogen peroxide response to peptide hormone positive regulation of smooth muscle cell proliferation response to cAMP positive regulation of nitric-oxide synthase biosynthetic process cellular response to cytokine stimulus cellular response to organic cyclic compound positive regulation of transcription of Notch receptor target cytokine-mediated signaling pathway interleukin-21-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway interleukin-9-mediated signaling pathway defense response regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6772 20846 Ensembl ENSG00000115415 ENSMUSG00000026104 UniProt P42224 P42225 RefSeq (mRNA) NM_007315 NM_139266 NM_001205313 NM_001205314 NM_009283 NM_001357627 RefSeq (protein) NP_009330 NP_644671 n/a Location (UCSC) Chr 2: 190.91 – 191.02 Mb Chr 1: 52.16 – 52.2 Mb PubMed search [3] [4]
Wikidata
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Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.^[5]