STAT3

STAT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AX3
Identifiers
Aliases	STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1
External IDs	OMIM: 102582; MGI: 103038; HomoloGene: 7960; GeneCards: STAT3; OMA:STAT3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,313,324 bp[1] End 42,388,568 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.82 cM Start 100,775,924 bp[2] End 100,830,366 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell pericardium lower lobe of lung lactiferous duct nipple right ventricle upper lobe of lung upper lobe of left lung vena cava epithelium of colon Top expressed in right lung lobe ankle granulocyte left lung decidua epithelium of stomach ankle joint stroma of bone marrow skin of external ear tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific nuclear receptor activity protein phosphatase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein kinase binding DNA binding sequence-specific DNA binding chromatin DNA binding protein homodimerization activity identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific signal transducer activity transcription factor binding CCR5 chemokine receptor binding glucocorticoid receptor binding Cellular component cytoplasm mitochondrion nucleus plasma membrane nucleoplasm RNA polymerase II transcription regulator complex mitochondrial inner membrane cytosol postsynaptic density Schaffer collateral - CA1 synapse glutamatergic synapse transcription regulator complex Biological process negative regulation of glycolytic process protein import into nucleus regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance positive regulation of gene silencing by miRNA radial glial cell differentiation stem cell population maintenance cellular response to hormone stimulus regulation of mitochondrial membrane permeability growth hormone receptor signaling pathway miRNA-mediated gene silencing by inhibition of translation eye photoreceptor cell differentiation positive regulation of metalloendopeptidase activity temperature homeostasis cell population proliferation response to leptin response to ethanol positive regulation of Notch signaling pathway negative regulation of cell population proliferation response to cytokine regulation of transcription, DNA-templated glucose homeostasis negative regulation of cell death transcription, DNA-templated positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of transcription, DNA-templated negative regulation of hydrogen peroxide biosynthetic process energy homeostasis viral process negative regulation of neuron death sexual reproduction phosphorylation leptin-mediated signaling pathway cellular response to organic cyclic compound negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II regulation of feeding behavior nervous system development positive regulation of ATP biosynthetic process intracellular receptor signaling pathway acute-phase response negative regulation of neuron migration receptor signaling pathway via JAK-STAT response to estradiol response to organic cyclic compound eating behavior somatic stem cell population maintenance regulation of multicellular organism growth human ageing response to peptide hormone cellular response to leptin stimulus regulation of cell cycle astrocyte differentiation signal transduction positive regulation of transcription by RNA polymerase II growth hormone receptor signaling pathway via JAK-STAT positive regulation of gene expression negative regulation of stem cell differentiation positive regulation of cell population proliferation mRNA transcription by RNA polymerase II inflammatory response positive regulation of erythrocyte differentiation T-helper 17 cell lineage commitment positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of tyrosine phosphorylation of STAT protein interleukin-15-mediated signaling pathway interleukin-7-mediated signaling pathway positive regulation of angiogenesis positive regulation of vascular endothelial cell proliferation cytokine-mediated signaling pathway interleukin-21-mediated signaling pathway interleukin-23-mediated signaling pathway interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway cellular response to cytokine stimulus interleukin-9-mediated signaling pathway modulation of chemical synaptic transmission postsynapse to nucleus signaling pathway negative regulation of autophagy positive regulation of cell migration positive regulation of NF-kappaB transcription factor activity defense response regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6774 20848 Ensembl ENSG00000168610 ENSMUSG00000004040 UniProt P40763 P42227 RefSeq (mRNA) NM_003150 NM_139276 NM_213662 NM_001369512 NM_001369513 NM_001369514 NM_001369516 NM_001369517 NM_001369518 NM_001369519 NM_001369520 NM_011486 NM_213659 NM_213660 RefSeq (protein) NP_003141 NP_644805 NP_998827 NP_001356441 NP_001356442 NP_001356443 NP_001356445 NP_001356446 NP_001356447 NP_001356448 NP_001356449 NP_035616 NP_998824 NP_998825 Location (UCSC) Chr 17: 42.31 – 42.39 Mb Chr 11: 100.78 – 100.83 Mb PubMed search [3] [4]
Wikidata
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Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene.^[5] It is a member of the STAT protein family.