STAT5

signal transducer and activator of transcription 5A
STAT5A
Identifiers
SymbolSTAT5A
Alt. symbolsSTAT5
NCBI gene6776
HGNC11366
OMIM601511
RefSeqNM_003152
UniProtP42229
Other data
LocusChr. 17 q11.2
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StructuresSwiss-model
DomainsInterPro
signal transducer and activator of transcription 5B
STAT5B
Identifiers
SymbolSTAT5B
NCBI gene6777
HGNC11367
OMIM604260
RefSeqNM_012448
UniProtP51692
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes, the proteins are 90% identical at the amino acid level.[1] STAT5 proteins are involved in cytosolic signalling and in mediating the expression of specific genes.[2] Aberrant STAT5 activity has been shown to be closely connected to a wide range of human cancers,[3] and silencing this aberrant activity is an area of active research in medicinal chemistry.[4]

  1. ^ Grimley PM, Dong F, Rui H (June 1999). "Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation". Cytokine Growth Factor Rev. 10 (2): 131–57. doi:10.1016/S1359-6101(99)00011-8. PMID 10743504.
  2. ^ Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL, Kitamura T (September 1999). "STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells". EMBO J. 18 (17): 4754–65. doi:10.1093/emboj/18.17.4754. PMC 1171548. PMID 10469654.
  3. ^ Tan SH, Nevalainen MT (June 2008). "Signal transducer and activator of transcription 5A/B in prostate and breast cancers" (PDF). Endocr. Relat. Cancer. 15 (2): 367–90. doi:10.1677/ERC-08-0013. PMC 6036917. PMID 18508994.
  4. ^ Cumaraswamy AA, Todic A, Resetca D, Minden MD, Gunning PT (January 2012). "Inhibitors of Stat5 protein signalling". MedChemComm. 3 (1): 22–27. doi:10.1039/C1MD00175B.