STAT5A

STAT5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y1U
Identifiers
Aliases	STAT5A, MGF, STAT5, signal transducer and activator of transcription 5A
External IDs	OMIM: 601511; MGI: 103036; HomoloGene: 20680; GeneCards: STAT5A; OMA:STAT5A - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,287,547 bp[1] End 42,311,943 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.77 cM Start 100,750,177 bp[2] End 100,775,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte left adrenal cortex right adrenal cortex subcutaneous adipose tissue tendon of biceps brachii blood gastric mucosa appendix lymph node Top expressed in lactiferous gland seminal vesicula Ileal epithelium thymus brown adipose tissue cumulus cell perirhinal cortex parotid gland granulocyte choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity protein tyrosine kinase activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process creatinine metabolic process positive regulation of endothelial cell proliferation receptor signaling pathway via JAK-STAT transcription, DNA-templated signal transduction valine metabolic process creatine metabolic process regulation of transcription by RNA polymerase II positive regulation of blood vessel endothelial cell migration fatty acid metabolic process taurine metabolic process succinate metabolic process regulation of multicellular organism growth citrate metabolic process oxaloacetate metabolic process regulation of transcription, DNA-templated allantoin metabolic process isoleucine metabolic process lactation 2-oxoglutarate metabolic process peptidyl-tyrosine phosphorylation interleukin-7-mediated signaling pathway growth hormone receptor signaling pathway via JAK-STAT interleukin-15-mediated signaling pathway cytokine-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-9-mediated signaling pathway reelin-mediated signaling pathway defense response regulation of cell population proliferation response to peptide hormone positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6776 20850 Ensembl ENSG00000126561 ENSMUSG00000004043 UniProt P42229 P42230 RefSeq (mRNA) NM_001288718 NM_001288719 NM_001288720 NM_003152 NM_001164062 NM_011488 NM_001362680 RefSeq (protein) NP_001275647 NP_001275648 NP_001275649 NP_003143 NP_001157534 NP_035618 NP_001349609 Location (UCSC) Chr 17: 42.29 – 42.31 Mb Chr 11: 100.75 – 100.78 Mb PubMed search [3] [4]
Wikidata
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Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene.^[5][6] STAT5A orthologs^[7] have been identified in several placentals for which complete genome data are available.