STAT6

STAT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OJ5, 4Y5W, 4Y5U
Identifiers
Aliases	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
External IDs	OMIM: 601512; MGI: 103034; HomoloGene: 2373; GeneCards: STAT6; OMA:STAT6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,095,408 bp[1] End 57,132,139 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.59 cM Start 127,478,855 bp[2] End 127,496,826 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right ovary left ovary canal of the cervix spleen gastric mucosa right adrenal cortex right uterine tube left uterine tube body of uterus Top expressed in granulocyte lumbar spinal ganglion mesenteric lymph nodes ascending aorta aortic valve thymus spleen lip stroma of bone marrow esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding sequence-specific DNA binding protein phosphatase binding DNA binding protein binding DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm membrane raft cytoplasm cytosol nuclear membrane Biological process regulation of transcription by RNA polymerase II T-helper 1 cell lineage commitment regulation of cell population proliferation response to cytokine interleukin-4-mediated signaling pathway regulation of transcription, DNA-templated cellular response to hydrogen peroxide mammary gland epithelial cell proliferation cellular response to reactive nitrogen species positive regulation of type I interferon production positive regulation of isotype switching to IgE isotypes mammary gland morphogenesis negative regulation of type 2 immune response negative regulation of transcription by RNA polymerase II signal transduction transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II cytokine-mediated signaling pathway positive regulation of cold-induced thermogenesis defense response receptor signaling pathway via JAK-STAT response to peptide hormone growth hormone receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6778 20852 Ensembl ENSG00000166888 ENSMUSG00000002147 UniProt P42226 P52633 RefSeq (mRNA) NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153 NM_009284 RefSeq (protein) NP_001171549 NP_001171550 NP_001171551 NP_001171552 NP_003144 NP_033310 Location (UCSC) Chr 12: 57.1 – 57.13 Mb Chr 10: 127.48 – 127.5 Mb PubMed search [3] [4]
Wikidata
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Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins.^[5] The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.^[5]