STX1A

STX1A
Identifiers
Aliases	STX1A, HPC-1, P35-1, STX1, SYN1A, syntaxin 1A
External IDs	OMIM: 186590; MGI: 109355; HomoloGene: 37941; GeneCards: STX1A; OMA:STX1A - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,719,672 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,079,954 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; Brodmann area 10; ; frontal pole; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; Brodmann area 9; ; pituitary gland; ; islet of Langerhans;
	Top expressed in
	barrel cortex; ; prefrontal cortex; ; primary motor cortex; ; piriform cortex; ; motor neuron; ; primary visual cortex; ; renal corpuscle; ; superior frontal gyrus; ; perirhinal cortex; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel inhibitor activity; transmembrane transporter binding; protein N-terminus binding; SNAP receptor activity; kinase binding; chloride channel inhibitor activity; protein heterodimerization activity; SNARE binding; protein binding; myosin binding; protein domain specific binding; protein-macromolecule adaptor activity; myosin head/neck binding; ATP-dependent protein binding; calcium-dependent protein binding;
Cellular component	integral component of membrane; cytosol; membrane; synaptic vesicle; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; voltage-gated potassium channel complex; plasma membrane; synapse; synaptic vesicle membrane; secretory granule; extracellular region; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; cell junction; SNARE complex; intracellular organelle; neuron projection; synaptobrevin 2-SNAP-25-syntaxin-1a complex; actomyosin; cytoplasmic vesicle; presynaptic membrane; postsynaptic density; presynaptic active zone membrane; nuclear membrane; integral component of plasma membrane; axon; protein-containing complex; acrosomal vesicle; integral component of synaptic vesicle membrane; glutamatergic synapse; integral component of presynaptic membrane; endomembrane system; intracellular anatomical structure;
Biological process	exocytosis; positive regulation of norepinephrine secretion; synaptic vesicle docking; secretion by cell; regulation of insulin secretion; positive regulation of catecholamine secretion; positive regulation of neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; regulation of exocytosis; response to gravity; vesicle docking; positive regulation of excitatory postsynaptic potential; positive regulation of exocytosis; intracellular protein transport; neurotransmitter transport; vesicle-mediated transport; calcium-ion regulated exocytosis; regulation of synaptic vesicle priming; protein localization to membrane; modulation of excitatory postsynaptic potential; synaptic vesicle fusion to presynaptic active zone membrane; SNARE complex assembly; cytokine-mediated signaling pathway; synaptic vesicle exocytosis; vesicle fusion; neurotransmitter secretion; glutamate secretion; protein sumoylation; insulin secretion; regulated exocytosis; hormone secretion; synaptic vesicle endocytosis; membrane fusion;
	Sources:Amigo / QuickGO
Orthologs
	6804
	20907
	ENSG00000106089
	ENSMUSG00000007207
	Q16623; Q75ME0
	O35526
	NM_001165903; NM_004603
	NM_016801; NM_001359179
	NP_001159375; NP_004594; NP_004594.1
	NP_058081; NP_001346108
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106089 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bennett MK, Calakos N, Scheller RH (July 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106089 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1321498-5] Bennett MK, Calakos N, Scheller RH (July 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.

[1]

[2]

[3]

[4]

[5]