SULF1

SULF1
Identifiers
Aliases	SULF1, HSULF-1, SULF-1, sulfatase 1
External IDs	OMIM: 610012; MGI: 2138563; HomoloGene: 49408; GeneCards: SULF1; OMA:SULF1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.2-q13.3 Start 69,466,624 bp[1] End 69,660,915 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A3 Start 12,762,501 bp[2] End 12,931,416 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura stromal cell of endometrium retinal pigment epithelium germinal epithelium right coronary artery Descending thoracic aorta ascending aorta saphenous vein Epithelium of choroid plexus visceral pleura Top expressed in vestibular membrane of cochlear duct otolith organ utricle Epithelium of choroid plexus hand retinal pigment epithelium ascending aorta aortic valve epithelium of lens internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function N-acetylglucosamine-6-sulfatase activity sulfuric ester hydrolase activity calcium ion binding catalytic activity hydrolase activity metal ion binding arylsulfatase activity glycosaminoglycan binding Cellular component endoplasmic reticulum membrane raft cell surface plasma membrane Golgi apparatus Golgi stack extracellular space collagen-containing extracellular matrix Biological process negative regulation of angiogenesis heparan sulfate proteoglycan metabolic process esophagus smooth muscle contraction glomerular basement membrane development regulation of fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway glomerular filtration negative regulation of endothelial cell proliferation negative regulation of prostatic bud formation kidney development positive regulation of Wnt signaling pathway vascular endothelial growth factor receptor signaling pathway embryonic skeletal system development bone development positive regulation of vascular endothelial growth factor production chondrocyte development apoptotic process metabolism positive regulation of BMP signaling pathway negative regulation of cell migration glial cell-derived neurotrophic factor receptor signaling pathway cartilage development innervation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23213 240725 Ensembl ENSG00000137573 ENSMUSG00000016918 UniProt Q8IWU6 Q8K007 RefSeq (mRNA) NM_001128204 NM_001128205 NM_001128206 NM_015170 NM_001198565 NM_001198566 NM_172294 RefSeq (protein) NP_001121676 NP_001121677 NP_001121678 NP_055985 NP_001185494 NP_001185495 NP_758498 Location (UCSC) Chr 8: 69.47 – 69.66 Mb Chr 1: 12.76 – 12.93 Mb PubMed search [3] [4]
Wikidata
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Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene.^[5]

Heparan sulfate proteoglycans (HSPGs) act as co-receptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endo-sulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.^[5]