Sacco may refer to:
- Sacco (clothing) (also Sakko), a type of jacket
- Sacco (river), a river of central Italy
- Sacco, Campania, a comune (municipality) in southern Italy
- Sacco chair, by Piero Gatti, Cesare Paolini, Franco Teodoro
- Ospedale Luigi Sacco, a hospital in Milan, Italy
- Savings and Credit Cooperative Society or Credit Union