Saint Sophia Church may refer to:
- Saint Sophia Church, Moscow, church in Moscow, Russia
- Saint Sophia Church (Nakhchivan-on-Don), church in Nakhchivan-on-Don, Rostov-on-Don city, Russia
- Church of Saint Sophia, Ohrid, church in Ohrid, North Macedonia
- Saint Sophia Church, Sofia, church in Sofia, Bulgaria
- St Sophia Greek Orthodox Church, Surry Hills, church in Surry Hills, New South Wales, Australia