Sakakibara (Japanese: 榊原) is a Japanese surname. Notable people with the surname include:
- Sakakibara Kenkichi (榊原 鍵吉, 1830–1894), a Japanese samurai and martial artist
- Nobuyuki Sakakibara, a Japanese businessman and mixed martial arts promoter
- Seito Sakakibara, alias of the perpetrator of the Kobe child murders
- Yui Sakakibara, a Japanese voice actress
- Yoshiko Sakakibara (born 1956), a Japanese voice actress
- Ikue Sakakibara (born 1959), a Japanese singer
- Sakakibara Yasumasa (榊原 康政, 1548–1606), a Japanese daimyō
- Saya Sakakibara (born 1999), a Japanese Australian cyclist