Salsolinol

Salsolinol
Names
	Other names 6,7-Dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
Identifiers
CAS Number	27740-96-1;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:113;
ChEMBL	ChEMBL1195032;
ChemSpider	82699;
KEGG	C09642;
PubChem CID	91588;
UNII	9ILS801M65 ;
	InChI InChI=1S/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3/t6-/m0/s1 Key: IBRKLUSXDYATLG-LURJTMIESA-N;
	SMILES CC1C2=CC(=C(C=C2CCN1)O)O;
Properties
Chemical formula	C10H13NO2
Molar mass	179.219 g·mol−1
Melting point	147–149 °C (297–300 °F; 420–422 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Salsolinol is a chemical compound derived from dopamine which plays a role in neurotransmission and is neurotoxic.

It has been linked to dopamine-related disorders including Parkinson's disease and alcohol use disorder. It is both synthesized in the human body and ingested in several common dietary sources.^[2]

^ Pesnot, Thomas; Gershater, Markus C.; Ward, John M.; Hailes, Helen C. (2011). "Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids". Chemical Communications. 47 (11): 3242–3244. doi:10.1039/C0CC05282E. PMID 21270984. Retrieved 24 January 2024.
^ Kurnik-Łucka, Magdalena; Panula, Pertti; Bugajski, Andrzej; Gil, Krzysztof (2018). "Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments". Neurotoxicity Research. 33 (2): 485–514. doi:10.1007/s12640-017-9818-6. PMC 5766726. PMID 29063289.

[property-1] Pesnot, Thomas; Gershater, Markus C.; Ward, John M.; Hailes, Helen C. (2011). "Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids". Chemical Communications. 47 (11): 3242–3244. doi:10.1039/C0CC05282E. PMID 21270984. Retrieved 24 January 2024.

[double-2] Kurnik-Łucka, Magdalena; Panula, Pertti; Bugajski, Andrzej; Gil, Krzysztof (2018). "Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments". Neurotoxicity Research. 33 (2): 485–514. doi:10.1007/s12640-017-9818-6. PMC 5766726. PMID 29063289.

[1]

[2]