Samir Mitragotri

Samir Mitragotri
Born (1971-05-28) 28 May 1971 (age 53)
Solapur, India
Alma materInstitute of Chemical Technology B.S., 1992
Massachusetts Institute of Technology M.S. and PhD, 1996
Known forDrug Delivery, Biomaterials
AwardsNational Academy of Engineering
National Academy of Medicine
Scientific career
FieldsChemical Engineering, Biomedical Engineering
InstitutionsHarvard University
Harvard John A. Paulson School of Engineering and Applied Sciences
Wyss Institute for Biologically Inspired Engineering
Doctoral advisorRobert S. Langer, Daniel Blankschtein
Doctoral studentsJulie Champion

Samir Mitragotri (born 28 May 1971) is an Indian American professor at Harvard University, an inventor, an entrepreneur, and a researcher in the fields of drug delivery and biomaterials.[1] He is currently the Hiller Professor of Bioengineering and Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard John A. Paulson School of Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering.[2] Prior to 2017, he was the Duncan and Suzanne Mellichamp Chair Professor at University of California, Santa Barbara.[3] [4]

Mitragotri has invented many novel drug delivery technologies, especially in the fields of transdermal, oral and targeted systems. He invented techniques to deliver drugs transdermally using low-frequency ultrasound,[5] pulsed microjet injector,[6] high throughput skin experimentation,[7] skin penetrating peptides[8] and ionic liquids.[9] He also invented intestinal patches and ionic liquids for oral delivery of proteins.[10][11] Mitragotri also pioneered nanoparticle-enabled cell therapies which use drug-loaded nanoparticles that hitch a ride on red blood cells, monocytes and other circulatory cells for tissue-specific delivery.[12] Mitragotri's technologies are used to develop next generation therapies against diabetes, cancer, psoriasis, hemorrhage, trauma and infections.

Mitragotri has published over 400 research publications, has given over 500 presentations worldwide, and is an inventor on over 200 patents/applications. His publications are cited with an h-index of 122.[13] Mitragotri is a member of the National Academy of Medicine and the National Academy of Inventors. He is also a member of the US National Academy of Engineering since 2015 for the development, clinical translation, and commercialization of transdermal drug delivery systems. He is a co-founder of several companies that are developing products based on his inventions. He received his PhD in chemical engineering at MIT and BS in chemical engineering from the Institute of Chemical Technology. Mitragotri serves on the editorial boards of several journals and has served as the founding editor-in-chief of Bioengineering and Translational Medicine.

  1. ^ "Mitragotri Laboratory". Drug Delivery. The President and Fellows of Harvard College. Retrieved April 22, 2018.
  2. ^ "Renowned bioengineer to join Harvard faculty". Harvard John A. Paulson School of Engineering and Applied Sciences. President and Fellows of Harvard College. Retrieved January 24, 2017.
  3. ^ "Endowed Chairs". UCSB Institutional Advancement, Office of Development. The Regents of the University of California. Retrieved October 14, 2014.
  4. ^ "People". UCSB Center for BioEngineering, Regents of the University of California. Archived from the original on October 17, 2014. Retrieved June 9, 2023.
  5. ^ Mitragotri, S.; Blankschtein, D.; Langer, R. (August 11, 1995). "Ultrasound-mediated transdermal protein delivery". Science. 269 (5225): 850–853. Bibcode:1995Sci...269..850M. doi:10.1126/science.7638603. PMID 7638603. S2CID 26069484.
  6. ^ Arora, A.; Hakim, I.; Baxter, J.; Rathnasingham, R.; Srinivasan, R.; Fletcher, D. A.; Mitragotri, S. (March 6, 2007). "Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets". Proceedings of the National Academy of Sciences. 104 (11): 4255–4260. Bibcode:2007PNAS..104.4255A. doi:10.1073/pnas.0700182104. PMC 1838589. PMID 17360511.
  7. ^ Karande, Pankaj; Jain, Amit; Mitragotri, Samir (January 4, 2004). "Discovery of transdermal penetration enhancers by high-throughput screening". Nature Biotechnology. 22 (2): 192–197. doi:10.1038/nbt928. PMID 14704682. S2CID 20478007.
  8. ^ Hsu, T.; Mitragotri, S. (September 8, 2011). "Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer". Proceedings of the National Academy of Sciences. 108 (38): 15816–15821. Bibcode:2011PNAS..10815816H. doi:10.1073/pnas.1016152108. PMC 3179050. PMID 21903933.
  9. ^ Zakrewsky, Michael; Lovejoy, Katherine S.; Kern, Theresa L.; Miller, Tarryn E.; Le, Vivian; Nagy, Amber; Goumas, Andrew M.; Iyer, Rashi S.; Del Sesto, Rico E.; Koppisch, Andrew T.; Fox, David T.; Mitragotri, Samir (September 16, 2014). "Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization". Proceedings of the National Academy of Sciences. 111 (37): 13313–13318. Bibcode:2014PNAS..11113313Z. doi:10.1073/pnas.1403995111. PMC 4169946. PMID 25157174.
  10. ^ Banerjee, Amrita; Ibsen, Kelly; Brown, Tyler; Chen, Renwei; Agatemor, Christian; Mitragotri, Samir (June 25, 2018). "Ionic liquids for oral insulin delivery". Proceedings of the National Academy of Sciences. 115 (28): 7296–7301. Bibcode:2018PNAS..115.7296B. doi:10.1073/pnas.1722338115. ISSN 0027-8424. PMC 6048483. PMID 29941553.
  11. ^ Whitehead, Kathryn; Shen, Zancong; Mitragotri, Samir (July 23, 2004). "Oral delivery of macromolecules using intestinal patches: applications for insulin delivery". Journal of Controlled Release. 98 (1): 37–45. doi:10.1016/j.jconrel.2004.04.013. ISSN 0168-3659. PMID 15245887.
  12. ^ Anselmo, Aaron C.; Gupta, Vivek; Zern, Blaine J.; Pan, Daniel; Zakrewsky, Michael; Muzykantov, Vladimir; Mitragotri, Samir (December 23, 2013). "Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells". ACS Nano. 7 (12): 11129–11137. doi:10.1021/nn404853z. PMC 4128963. PMID 24182189.
  13. ^ "Samir Mitragotri". Google Scholar. Retrieved May 14, 2020.