The San Xavier Indian Reservation (O’odham: Wa:k) is an Indian reservation of the Tohono O’odham Nation located near Tucson, Arizona, in the Sonoran Desert. The San Xavier Reservation lies in the southwestern part of the Tucson metropolitan area and consists of 111.543 sq mi (288.90 km2) of land area, about 2.5 percent of the Tohono O’odham Nation. It had a 2000 census resident population of 2,053 persons, or 19 percent of the Tohono O’odham population.