Scavenger receptor (immunology)

Not to be confused with Scavenger receptor (endocrinology).
Scavenger receptor
Identifiers
SymbolScavenger receptor
OPM superfamily456
OPM protein5ktf
Membranome4

Scavenger receptors are a large and diverse superfamily of cell surface receptors. Its properties were first recorded in 1970 by Drs. Brown and Goldstein, with the defining property being the ability to bind and remove modified low density lipoproteins (LDL).[1] Today scavenger receptors are known to be involved in a wide range of processes, such as: homeostasis, apoptosis, inflammatory diseases and pathogen clearance. Scavenger receptors are mainly found on myeloid cells and other cells that bind to numerous ligands, primarily endogenous and modified host-molecules together with pathogen-associated molecular patterns(PAMPs), and remove them.[2] The Kupffer cells in the liver are particularly rich in scavenger receptors, includes SR-A I, SR-A II, and MARCO.[3]

  1. ^ Patten DA, Shetty S (2018). "More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking". Frontiers in Immunology. 9: 2904. doi:10.3389/fimmu.2018.02904. PMC 6315190. PMID 30631321.
  2. ^ PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DM, Drickamer K, Febbraio M, et al. (May 2017). "A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease". Journal of Immunology. 198 (10): 3775–3789. doi:10.4049/jimmunol.1700373. PMC 5671342. PMID 28483986.
  3. ^ Murphy K, Weaver C (2017). Janeway's immunobiology (Ninth ed.). New York, NY, USA. ISBN 978-0-8153-4505-3. OCLC 933586700.{{cite book}}: CS1 maint: location missing publisher (link)