Secretin receptor

SCTR
Identifiers
Aliases	SCTR, SR, secretin receptor
External IDs	OMIM: 182098; MGI: 2441720; HomoloGene: 68290; GeneCards: SCTR; OMA:SCTR - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	119,525,301 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	119,991,266 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; testicle; ; islet of Langerhans; ; duodenum; ; right lung; ; upper lobe of left lung; ; body of stomach; ; human kidney; ; gallbladder; ; right uterine tube;
	Top expressed in
	muscle of thigh; ; epithelium of stomach; ; morula; ; knee joint; ; lumbar subsegment of spinal cord; ; soleus muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; temporal muscle; ; upper arm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; secretin receptor activity; peptide hormone binding; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; cytoplasmic microtubule; plasma membrane; membrane;
Biological process	cell surface receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway; brain development; diet induced thermogenesis; cellular water homeostasis; response to nutrient levels; regulation of appetite; positive regulation of cAMP-mediated signaling; regulation of synaptic plasticity;
	Sources:Amigo / QuickGO
Orthologs
	6344
	319229
	ENSG00000080293
	ENSMUSG00000026387
	P47872
	Q5FWI2
	NM_002980
	NM_001012322; NM_001311077
	NP_002971
	NP_001012322; NP_001298006
	Wikidata
View/Edit Human	View/Edit Mouse

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080293 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026387 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080293 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026387 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12529936-5] Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Receptors & Channels. 8 (3–4): 189–200. doi:10.1080/10606820213686. PMID 12529936.

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