Selective organ targeting (SORT) is a novel approach in the field of targeted drug delivery that systematically engineers multiple classes of lipid nanoparticles (LNPs) to enable targeted delivery of therapeutics to specific organs in the body. The SORT molecule alters tissue tropism by adjusting the composition and physical characteristics of the nanoparticle. Adding a permanently cationic lipid, a permanently anionic lipid, or ionizable amino lipid increases delivery to the lung, spleen, and liver, respectively.[1][2][3] SORT LNPs utilize SORT molecules to accurately tune and mediate gene delivery and editing, resulting in predictable and manageable protein synthesis from mRNA in particular organ(s),[1] which can potentially improve the efficacy of drugs while reducing side effects.
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