Self is a surname. Notable people with the surname include:
- Austin Wayne Self (born 1996), American racing driver
- Bill Self (born 1962), American college basketball coach at the University of Kansas
- David Self (born January 8, 1970), an American screenwriter
- David Self, a colorist for comics such as WildStorm's Red
- Doris Self (1925–2006), American video game competitor
- Keith Self (born 1953), American politician
- Michael Self (born 1990), American racing driver
- Will Self (born 1961), English novelist
- William Edwin Self (1921–2010), American actor and producer
- William Self (Organist) (1906–1998), American musician