Semapimod

Semapimod
Clinical data
ATC code
  • none
Identifiers
  • N,N'-bis[3,5-bis[N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl] decanediamide tetrahydrochloride
CAS Number
PubChem CID
UNII
ChEMBL
Chemical and physical data
FormulaC34H56Cl4N18O2
Molar mass890.75 g·mol−1
3D model (JSmol)
  • CC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C.Cl.Cl.Cl.Cl
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Semapimod (INN), formerly known as CNI-1493, is an investigational new drug which has anti-inflammatory,[1] anti-cytokine,[2] immunomodulatory,[3] antiviral[4] and antimalarial[5] properties.

  1. ^ Bianchi M, Ulrich P, Bloom O, Meistrell M, Zimmerman GA, Schmidtmayerova H, et al. (March 1995). "An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality". Molecular Medicine. 1 (3): 254–66. doi:10.1007/BF03401550. PMC 2229913. PMID 8529104.
  2. ^ Bianchi M, Bloom O, Raabe T, Cohen PS, Chesney J, Sherry B, et al. (March 1996). "Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone". The Journal of Experimental Medicine. 183 (3): 927–36. doi:10.1084/jem.183.3.927. PMC 2192362. PMID 8642296.
  3. ^ Martiney JA, Rajan AJ, Charles PC, Cerami A, Ulrich PC, Macphail S, et al. (June 1998). "Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent" (Free full text). Journal of Immunology. 160 (11): 5588–95. doi:10.4049/jimmunol.160.11.5588. PMID 9605164. S2CID 12503616.
  4. ^ Hauber I, Bevec D, Heukeshoven J, Krätzer F, Horn F, Choidas A, et al. (January 2005). "Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy". The Journal of Clinical Investigation (Free full text). 115 (1): 76–85. doi:10.1172/JCI21949. PMC 539192. PMID 15630446.
  5. ^ Specht S, Sarite SR, Hauber I, Hauber J, Görbig UF, Meier C, et al. (May 2008). "The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase". Parasitology Research. 102 (6): 1177–84. doi:10.1007/s00436-008-0891-x. PMID 18256853. S2CID 27771876.