Separase

Separase
Identifiers
EC no.3.4.22.49
CAS no.351527-77-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
ESPL1
Identifiers
AliasesESPL1, ESP1, SEPA, EPAS1, Separase, extra spindle pole bodies like 1, separase
External IDsOMIM: 604143; MGI: 2146156; HomoloGene: 32151; GeneCards: ESPL1; OMA:ESPL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012291

NM_001014976
NM_001356312

RefSeq (protein)

NP_036423

NP_001014976
NP_001343241

Location (UCSC)Chr 12: 53.27 – 53.29 MbChr 15: 102.2 – 102.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase.[5] In humans, separin is encoded by the ESPL1 gene.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135476Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058290Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "ESPL1 - Separin - Homo sapiens (Human) - ESPL1 gene & protein". Uniprot.org. 2010-10-05. Retrieved 2016-05-14.
  6. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.