Serapion is a given name, a variant of Seraphin.
People called Serapion:
- Serapion of Alexandria (3rd century BC), Greek physician
- Serapion (strategos), probably negotiated in 48 BC for Caesar with Achillas, strategos of Cyprus in 43 BC, executed in 41 BC
- Mara bar Serapion (1st century AD), Syrian stoic
- Serapion of Macedonia (d. 195), martyr
- Serapion of Antioch (c. 200 AD), Patriarch of Antioch
- Serapion (3rd century AD), neoplatonic philosopher, one of the disciples of Plotinus
- Serapion (4th century AD), author of the Sacramentary of Serapion of Thmuis
- Serapion the Sindonite (4th century AD), Egyptian monk and saint
- Yahya ibn Sarafyun (9th century), also known as Serapion the Elder or Johannes Serapion, Christian physician who wrote two medical compilations in Syriac
- Serapion of Algiers (1179–1240), Mercedarian saint
- Serapion the Younger (c. 12th century), physician who wrote The Book of Simple Medicine (in Arabic)
- Serapion of Vladimir (13th century), bishop of Vladimir
- Serapion of Novgorod (d. 1516), Russian archbishop
- Serapion (Coptic bishop of Los Angeles) (b. 1951)