Serine/arginine-rich splicing factor 1

SRSF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X4A, 2M7S, 2M8D, 2O3D, 3BEG, 4C0O
Identifiers
Aliases	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a, ASF/SF2, serine/arginine-rich splicing factor 1, serine and arginine rich splicing factor 1
External IDs	OMIM: 600812; MGI: 98283; HomoloGene: 31411; GeneCards: SRSF1; OMA:SRSF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	58,007,346 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	87,944,581 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; epithelium of colon; ; left ovary; ; body of uterus; ; rectum; ; Achilles tendon; ; right ovary; ; canal of the cervix; ; right uterine tube;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; tail of embryo; ; genital tubercle; ; spermatocyte; ; yolk sac; ; superior frontal gyrus; ; lip; ; esophagus; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RS domain binding; protein binding; RNA binding; nucleic acid binding; mRNA binding; protein kinase B binding; DNA topoisomerase binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; exon-exon junction complex; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; cardiac muscle contraction; mRNA processing; in utero embryonic development; mRNA export from nucleus; mRNA splice site selection; mRNA 5'-splice site recognition; mRNA 3'-end processing; liver regeneration; alternative mRNA splicing, via spliceosome; RNA splicing; oligodendrocyte differentiation; RNA export from nucleus; positive regulation of RNA splicing; transport; regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6426
	110809
	ENSG00000136450
	ENSMUSG00000018379
	Q07955
	Q6PDM2
	NM_001078166; NM_006924
	NM_001078167; NM_173374
	NP_001071634; NP_008855
	NP_001071635; NP_775550
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene.^[5] ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing.^[6]^[7]^[8] SRSF1 is the gene that codes for ASF/SF2^[9] and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa.^[10] ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing.^[7] In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)".
^ Kim DJ, Oh B, Kim YY (Jan 2009). "Splicing factor ASF/SF2 and transcription factor PPAR-gamma cooperate to directly regulate transcription of uncoupling protein-3". Biochemical and Biophysical Research Communications. 378 (4): 877–82. doi:10.1016/j.bbrc.2008.12.009. PMID 19073146.
^ ^a ^b Zuo P, Manley JL (Dec 1993). "Functional domains of the human splicing factor ASF/SF2". The EMBO Journal. 12 (12): 4727–37. doi:10.1002/j.1460-2075.1993.tb06161.x. PMC 413918. PMID 8223481.
^ Li X, Manley JL (Aug 2005). "Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability". Cell. 122 (3): 365–78. doi:10.1016/j.cell.2005.06.008. PMID 16096057. S2CID 14126033.
^ Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG (Sep 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–9. doi:10.1006/geno.1995.1216. PMID 8530103.
^ Krainer AR, Conway GC, Kozak D (Jul 1990). "The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites". Cell. 62 (1): 35–42. doi:10.1016/0092-8674(90)90237-9. PMID 2364434. S2CID 29839844.
^ Michlewski G, Sanford JR, Cáceres JF (Apr 2008). "The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1". Molecular Cell. 30 (2): 179–89. doi:10.1016/j.molcel.2008.03.013. PMID 18439897.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)".

[kim-6] Kim DJ, Oh B, Kim YY (Jan 2009). "Splicing factor ASF/SF2 and transcription factor PPAR-gamma cooperate to directly regulate transcription of uncoupling protein-3". Biochemical and Biophysical Research Communications. 378 (4): 877–82. doi:10.1016/j.bbrc.2008.12.009. PMID 19073146.

[zuo-7] Zuo P, Manley JL (Dec 1993). "Functional domains of the human splicing factor ASF/SF2". The EMBO Journal. 12 (12): 4727–37. doi:10.1002/j.1460-2075.1993.tb06161.x. PMC 413918. PMID 8223481.

[li-8] Li X, Manley JL (Aug 2005). "Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability". Cell. 122 (3): 365–78. doi:10.1016/j.cell.2005.06.008. PMID 16096057. S2CID 14126033.

[bermingham-9] Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG (Sep 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–9. doi:10.1006/geno.1995.1216. PMID 8530103.

[krainer-10] Krainer AR, Conway GC, Kozak D (Jul 1990). "The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites". Cell. 62 (1): 35–42. doi:10.1016/0092-8674(90)90237-9. PMID 2364434. S2CID 29839844.

[michlewski-11] Michlewski G, Sanford JR, Cáceres JF (Apr 2008). "The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1". Molecular Cell. 30 (2): 179–89. doi:10.1016/j.molcel.2008.03.013. PMID 18439897.

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