Serine C-palmitoyltransferase

Serine palmitoyltransferase
Crystallographic structure of serine palmitoyltransferase from S. paucimobilis. The cofactor PLP is visible in the center.[1]
Identifiers
Symbol	SPT1
PDB	2JG2
UniProt	Q93UV0
Other data
EC number	2.3.1.50
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In enzymology, a serine C-palmitoyltransferase (EC 2.3.1.50) is an enzyme that catalyzes the chemical reaction:^[2][3]

palmitoyl-CoA + L-serine ${\displaystyle \rightleftharpoons }$ CoA + 3-dehydro-D-sphinganine + CO₂

Thus, the two substrates of this enzyme are palmitoyl-CoA and L-serine, whereas its 3 products are CoA, 3-dehydro-D-sphinganine, and CO₂.^[4][5] This reaction is a key step in the biosynthesis of sphingosine which is a precursor of many other sphingolipids.^[3]

This enzyme participates in sphingolipid metabolism. It employs one cofactor, pyridoxal phosphate.