The Seton Lake First Nation, a.k.a. the Seton Lake Indian Band, is a First Nations government located in the Central Interior-Fraser Canyon region of the Canadian province of British Columbia. It is a member of the Lillooet Tribal Council, which is the largest grouping of band governments of the St'at'imc people (a.k.a. the Lillooet people). Other St'at'imc governments include the smaller In-SHUCK-ch Nation on the lower Lillooet River to the southwest, and the independent N'quatqua First Nation at the farther end of Anderson Lake from Seton Portage, which is the location of three of the band's reserve communities.
The Seton Lake First Nation's offices are located at Shalalth, British Columbia, where a School District #74 public school is in operation, teaching St'at'imcets language and St'at'imc culture in addition to regular curriculum.