Sex-limited genes

Sex-limited genes are genes that are present in both sexes of sexually reproducing species but are expressed in only one sex and have no penetrance, or are simply 'turned off' in the other.[1] In other words, sex-limited genes cause the two sexes to show different traits or phenotypes, despite having the same genotype. This term is restricted to autosomal traits, and should not be confused with sex-linked characteristics, which have to do with genetic differences on the sex chromosomes (see sex-determination system). Sex-limited genes are also distinguished from sex-influenced genes, where the same gene will show differential expression in each sex. Sex-influenced genes commonly show a dominant/recessive relationship, where the same gene will have a dominant effect in one sex and a recessive effect in the other (for example, male pattern baldness). However, the resulting phenotypes caused by sex-limited genes are present in only one sex and can be seen prominently in various species that typically show high sexual dimorphism.[2]

Sex-limited genes are responsible for sexual dimorphism, which is a phenotypic (directly observable) difference between males and females of the same species regardless of genotype.[3] These differences can be reflected in size, color, behavior (ex: levels of aggression), and morphology. An example of sex-limited genes are genes which control horn development in sheep:[4] while both males and females possess the same genes controlling horn development, they are only expressed in males. Sex-limited genes are also responsible for some female beetles' inability to grow exaggerated mandibles,[5] research that is discussed in detail later in this article.

Sex-limited genes were first hypothesized by Charles Darwin and though he was unsuccessful in distinguishing the previously mentioned sex-linked traits, his hypothesis was the starting point for future study of the subject.[6] His studies on sex-limited traits have been further substantiated and supported over time, distinguishing sex-limited genes and sex-linked traits. Modern study of sex-limited genes includes research on epigenetics, which is the study of inheritable phentotypic changes with no change in DNA sequence. Modern research suggests that a substantial portion of the expression of sex-limited genes and sexual dimorphism may be influenced by certain epigenetic marks.[7]

The purpose of sex-limited genes is to resolve sexual conflict. These genes try to resolve the "push-pull" between males and females over trait values for optimal phenotype. Without these genes, organisms would be forced to settle on an average trait value, incurring costs on both sexes. With these genes, it is possible to 'turn off' the genes in one sex, allowing both sexes to attain (or at least, approach very closely) their optimal phenotypes. This phenotypic variation can play a key role in the evolution of various species and their sexual differentiation.[3]

  1. ^ Pierce, Benjamin (2019). Genetics A Conceptual Approach Seventh Edition. Macmillan Publishers. p. 129. ISBN 978-1-319-29714-5.
  2. ^ Owens, I. P. F.; Hartley, I. R. (1998-03-07). "Sexual dimorphism in birds: why are there so many different forms of dimorphism?". Proceedings of the Royal Society of London. Series B: Biological Sciences. 265 (1394): 397–407. doi:10.1098/rspb.1998.0308. ISSN 0962-8452. PMC 1688905.
  3. ^ a b Rhen, Turk (2000). "Sex-Limited Mutations and the Evolution of Sexual Dimorphism". Evolution. 54 (1): 37–43. doi:10.1111/j.0014-3820.2000.tb00005.x. ISSN 1558-5646. PMID 10937181. S2CID 11789985.
  4. ^ Montgomery, G. W.; Henry, H. M.; Dodds, K. G.; Beattie, A. E.; Wuliji, T.; Crawford, A. M. (1996-09-01). "Mapping the Horns (Ho) Locus in Sheep: A Further Locus Controlling Horn Development in Domestic Animals". Journal of Heredity. 87 (5): 358–363. doi:10.1093/oxfordjournals.jhered.a023014. ISSN 0022-1503. PMID 8904835.
  5. ^ Hosken, D.J.; et al. (2012). "Intralocus Sexual Conflict Unresolved By Sex-Limited Trait Expression". Current Biology. 20 (22): 2036–2039. doi:10.1016/j.cub.2010.10.023. PMID 21055943. S2CID 15482973.
  6. ^ Cite error: The named reference :3 was invoked but never defined (see the help page).
  7. ^ Gabory, Anne; Attig, Linda; Junien, Claudine (2009-05-25). "Sexual dimorphism in environmental epigenetic programming" (PDF). Molecular and Cellular Endocrinology. 304 (1–2): 8–18. doi:10.1016/j.mce.2009.02.015. ISSN 0303-7207. PMID 19433243. S2CID 26141184.