Sex hormone-binding globulin

SHBG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSHBG, ABP, SBP, TEBG, sex hormone binding globulin, Sex hormone-binding globulin
External IDsOMIM: 182205; MGI: 98295; HomoloGene: 813; GeneCards: SHBG; OMA:SHBG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011367

RefSeq (protein)

NP_035497

Location (UCSC)Chr 17: 7.61 – 7.63 MbChr 11: 69.51 – 69.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Androgen-binding protein, Sex hormone-binding globulin
Identifiers
SymbolSHBG
Alt. symbolsABP
NCBI gene6462
HGNC10839
OMIM182205
RefSeqNM_001040
UniProtP04278
Other data
LocusChr. 17 p13-p12
Search for
StructuresSwiss-model
DomainsInterPro

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the Sertoli cells in the seminiferous tubules of the testis, it is called androgen-binding protein (ABP).[5][6]

Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. SHBG is found in all vertebrates apart from birds.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129214Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005202Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bardin CW, Musto N, Gunsalus G, Kotite N, Cheng SL, Larrea F, Becker R (1981). "Extracellular androgen binding proteins". Annual Review of Physiology. 43: 189–98. doi:10.1146/annurev.ph.43.030181.001201. PMID 7011179.
  6. ^ Cite error: The named reference Hansson_1976 was invoked but never defined (see the help page).
  7. ^ Hammond GL (September 2011). "Diverse roles for sex hormone-binding globulin in reproduction". Biology of Reproduction. 85 (3): 431–41. doi:10.1095/biolreprod.111.092593. PMC 4480437. PMID 21613632.