Short QT syndrome

Short QT syndrome
Schematic representation of normal ECG trace (sinus rhythm), with waves, segments, and intervals labeled
SpecialtyCardiology
SymptomsPassing out, sudden cardiac death[1]
CausesGenetic
Diagnostic methodElectrocardiogram (ECG)[1]
TreatmentMedication, implantable cardioverter defibrillator (ICD)[1]
MedicationQuinidine, Flecainide[1]
PrognosisRisk of sudden cardiac death 0.8% per year[2]
Frequency<300 cases reported worldwide[1]

Short QT syndrome (SQT) is a very rare genetic disease of the electrical system of the heart, and is associated with an increased risk of abnormal heart rhythms and sudden cardiac death.[1] The syndrome gets its name from a characteristic feature seen on an electrocardiogram (ECG) – a shortening of the QT interval. It is caused by mutations in genes encoding ion channels that shorten the cardiac action potential, and appears to be inherited in an autosomal dominant pattern.[1] The condition is diagnosed using a 12-lead ECG.[2] Short QT syndrome can be treated using an implantable cardioverter-defibrillator or medications including quinidine.[3] Short QT syndrome was first described in 2000,[4] and the first genetic mutation associated with the condition was identified in 2004.[5]

  1. ^ a b c d e f g Cite error: The named reference Bjerregaard_2018 was invoked but never defined (see the help page).
  2. ^ a b Cite error: The named reference Bjerregaard_2013 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Schimpf_2005 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Gussak_2000 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Brugada_2004 was invoked but never defined (see the help page).