Sizhou, Si Prefecture, or Si Subprefecture was a zhou of imperial China variously placed in what is now Xuyi County, Jiangsu, or nearby Si County, Anhui, both in China. Named for the Si River, it existed intermittently from 580 to 1912, during which time the relative position of a zhou within Chinese administrations varied. The same name Sizhou was used for the town used as the seat of the prefectural or subprefectural government, which also varied, and is preserved in modern Anhui's Si County and Sicheng.