Sialidase-1

NEU1
Identifiers
Aliases	NEU1, NANH, NEU, SIAL1, neuraminidase 1 (lysosomal sialidase), neuraminidase 1
External IDs	OMIM: 608272; MGI: 97305; HomoloGene: 375; GeneCards: NEU1; OMA:NEU1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,862,905 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,154,929 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right adrenal cortex; ; bone marrow cells; ; left adrenal gland; ; placenta; ; left adrenal cortex; ; gallbladder; ; human kidney; ; duodenum; ; renal cortex;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; granulocyte; ; ileum; ; seminal vesicula; ; yolk sac; ; gallbladder; ; left colon; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	exo-alpha-(2->3)-sialidase activity; exo-alpha-(2->8)-sialidase activity; exo-alpha-(2->6)-sialidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; exo-alpha-sialidase activity; protein binding; alpha-sialidase activity;
Cellular component	cytoplasmic vesicle; intracellular membrane-bounded organelle; lysosomal membrane; extracellular exosome; lysosome; plasma membrane; lysosomal lumen; cell junction; membrane; extracellular region; specific granule lumen; cytoplasm;
Biological process	ganglioside catabolic process; lipid catabolic process; lipid metabolism; metabolism; oligosaccharide catabolic process; glycosphingolipid metabolic process; neutrophil degranulation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4758
	18010
ENSG00000227129; ENSG00000184494; ENSG00000223957; ENSG00000234846; ENSG00000204386;
	ENSG00000234343; ENSG00000227315; ENSG00000228691
	ENSMUSG00000007038
	Q99519
	O35657
	NM_000434
	NM_010893
	NP_000425
	NP_035023
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000184494, ENSG00000223957, ENSG00000234846, ENSG00000204386, ENSG00000234343, ENSG00000227315, ENSG00000228691 GRCh38: Ensembl release 89: ENSG00000227129, ENSG00000184494, ENSG00000223957, ENSG00000234846, ENSG00000204386, ENSG00000234343, ENSG00000227315, ENSG00000228691 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NEU1 sialidase 1 (lysosomal sialidase)".
^ Pshezhetsky AV, Richard C, Michaud L, Igdoura S, Wang S, Elsliger MA, Qu J, Leclerc D, Gravel R, Dallaire L, Potier M (March 1997). "Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis". Nat. Genet. 15 (3): 316–20. doi:10.1038/ng0397-316. PMID 9054950. S2CID 31588761.

[refGRCh38Ensembl-1] ENSG00000184494, ENSG00000223957, ENSG00000234846, ENSG00000204386, ENSG00000234343, ENSG00000227315, ENSG00000228691 GRCh38: Ensembl release 89: ENSG00000227129, ENSG00000184494, ENSG00000223957, ENSG00000234846, ENSG00000204386, ENSG00000234343, ENSG00000227315, ENSG00000228691 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007038 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NEU1 sialidase 1 (lysosomal sialidase)".

[pmid9054950-6] Pshezhetsky AV, Richard C, Michaud L, Igdoura S, Wang S, Elsliger MA, Qu J, Leclerc D, Gravel R, Dallaire L, Potier M (March 1997). "Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis". Nat. Genet. 15 (3): 316–20. doi:10.1038/ng0397-316. PMID 9054950. S2CID 31588761.

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