Sialidase-2

NEU2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SNT, 1SO7, 1VCU, 2F0Z, 2F10, 2F11, 2F12, 2F13, 2F24, 2F25, 2F26, 2F27, 2F28, 2F29, 4NC5, 4NCS
Identifiers
Aliases	NEU2, SIAL2, neuraminidase 2 (cytosolic sialidase), neuraminidase 2
External IDs	OMIM: 605528; MGI: 1344417; HomoloGene: 3927; GeneCards: NEU2; OMA:NEU2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,035,057 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,525,567 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of leg; ; skin of abdomen; ; connective tissue; ; adipose tissue; ; nervous system; ; subcutaneous adipose tissue; ; tibial nerve;
	Top expressed in
	temporal muscle; ; esophagus; ; triceps brachii muscle; ; right kidney; ; sternocleidomastoid muscle; ; respiratory epithelium; ; olfactory epithelium; ; vastus lateralis muscle; ; lip; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	exo-alpha-(2->6)-sialidase activity; exo-alpha-(2->8)-sialidase activity; hydrolase activity, acting on glycosyl bonds; protein binding; exo-alpha-(2->3)-sialidase activity; hydrolase activity; exo-alpha-sialidase activity;
Cellular component	cytoplasm; membrane; intracellular membrane-bounded organelle; cytosol; catalytic complex;
Biological process	glycosphingolipid metabolic process; lipid metabolism; lipid catabolic process; oligosaccharide catabolic process; metabolism; ganglioside catabolic process; cellular oligosaccharide catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4759
	23956
	ENSG00000115488
	ENSMUSG00000079434
	Q9Y3R4
	Q9JMH3
	NM_005383
	NM_001160163; NM_001160164; NM_001160165; NM_015750
	NP_005374
	NP_001153635; NP_001153636; NP_001153637; NP_056565
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.^[5]^[6]^[7]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115488 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079434 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics. 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.
^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem. 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.
^ ^a ^b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115488 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079434 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191093-5] Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics. 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.

[pmid14613940-6] Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem. 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.

[entrez-7] "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".

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