Sialidase-3

NEU3
Identifiers
Aliases	NEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDs	OMIM: 604617; MGI: 1355305; HomoloGene: 4847; GeneCards: NEU3; OMA:NEU3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,018,893 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,477,624 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; sural nerve; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; right testis;
	Top expressed in
	cumulus cell; ; epithelium of small intestine; ; thymus; ; embryo; ; muscle of thigh; ; left lung lobe; ; transitional epithelium of urinary bladder; ; ectoderm; ; otic vesicle; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	alpha-sialidase activity; exo-alpha-(2->6)-sialidase activity; exo-alpha-(2->8)-sialidase activity; hydrolase activity, acting on glycosyl bonds; exo-alpha-(2->3)-sialidase activity; hydrolase activity; exo-alpha-sialidase activity;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; membrane; plasma membrane; integral component of plasma membrane;
Biological process	glycosphingolipid metabolic process; lipid metabolism; lipid catabolic process; oligosaccharide catabolic process; metabolism; ganglioside catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10825
	50877
	ENSG00000162139
	ENSMUSG00000035239
	Q9UQ49
	Q9JMH7
	NM_006656
	NM_016720
NP_006647; NP_001354789; NP_001354790; NP_001354791; NP_001354792;
	NP_001354793; NP_001354794; NP_001354795; NP_001354796
	NP_057929
	Wikidata
View/Edit Human	View/Edit Mouse

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162139 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035239 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
^ "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162139 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035239 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10405317-5] Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.

[entrez-6] "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".

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