Sialin

SLC17A5
Identifiers
Aliases	SLC17A5, AST, ISSD, NSD, SD, SIALIN, SIASD, SLD, solute carrier family 17 member 5
External IDs	OMIM: 604322; MGI: 1924105; HomoloGene: 56571; GeneCards: SLC17A5; OMA:SLC17A5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,653,992 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,495,323 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; stromal cell of endometrium; ; mucosa of sigmoid colon; ; germinal epithelium; ; mucosa of ileum; ; jejunal mucosa; ; visceral pleura; ; right lobe of thyroid gland; ; synovial joint; ; islet of Langerhans;
	Top expressed in
	epithelium of small intestine; ; lacrimal gland; ; parotid gland; ; submandibular gland; ; proximal tubule; ; right kidney; ; renal corpuscle; ; ileum; ; human kidney; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate:proton symporter activity; sialic acid transmembrane transporter activity; symporter activity; sialic acid:proton symporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; synaptic vesicle membrane; lysosomal membrane; cell junction; lysosome; cytoplasmic vesicle; cytosol;
Biological process	sialic acid transport; ion transport; anion transport; amino acid transport; transmembrane transport; carboxylic acid transmembrane transport; transport; response to bacterium; carbohydrate transmembrane transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	26503
	235504
	ENSG00000119899
	ENSMUSG00000049624
	Q9NRA2
	Q8BN82
	NM_012434
	NM_001276452; NM_172773
NP_036566; NP_001369558; NP_001369559; NP_001369560; NP_001369561;
	NP_001369562; NP_001369563; NP_001369564; NP_001369565
	NP_001263381; NP_766361
	Wikidata
View/Edit Human	View/Edit Mouse

Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049624 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5".
^ Haataja L, Schleutker J, Laine AP, Renlund M, Savontaus ML, Dib C, Weissenbach J, Peltonen L, Aula P (June 1994). "The genetic locus for free sialic acid storage disease maps to the long arm of chromosome 6". Am. J. Hum. Genet. 54 (6): 1042–9. PMC 1918202. PMID 8198127.
^ Verheijen FW, Verbeek E, Aula N, Beerens CE, Havelaar AC, Joosse M, Peltonen L, Aula P, Galjaard H, van der Spek PJ, Mancini GM (December 1999). "A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases". Nat. Genet. 23 (4): 462–5. doi:10.1038/70585. PMID 10581036. S2CID 5709302.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119899 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049624 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5".

[pmid8198127-6] Haataja L, Schleutker J, Laine AP, Renlund M, Savontaus ML, Dib C, Weissenbach J, Peltonen L, Aula P (June 1994). "The genetic locus for free sialic acid storage disease maps to the long arm of chromosome 6". Am. J. Hum. Genet. 54 (6): 1042–9. PMC 1918202. PMID 8198127.

[pmid10581036-7] Verheijen FW, Verbeek E, Aula N, Beerens CE, Havelaar AC, Joosse M, Peltonen L, Aula P, Galjaard H, van der Spek PJ, Mancini GM (December 1999). "A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases". Nat. Genet. 23 (4): 462–5. doi:10.1038/70585. PMID 10581036. S2CID 5709302.

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