Siege of Antwerp may refer to:
- Fall of Antwerp, a 1584–1585 siege of Antwerp conducted by Spanish forces against a Dutch garrison during the Eighty Years' War
- Siege of Antwerp (1789-1790), conducted by the Belgian Patriot army against the Austrians during the Brabant Revolution.
- Siege of Antwerp (1814), conducted by Allied forces against a French garrison during the War of the Sixth Coalition.
- Siege of Antwerp (1832), conducted by French forces against a Dutch garrison after the Belgian Revolution's Ten Days' Campaign.
- Siege of Antwerp (1914), conducted by German forces against a Belgian and British garrison during World War I.