Signal peptide

Identifiers
SymbolN/A
OPM superfamily256
OPM protein1skh

A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long)[1] present at the N-terminus (or occasionally nonclassically at the C-terminus[2] or internally) of most newly synthesized proteins that are destined toward the secretory pathway.[3] These proteins include those that reside either inside certain organelles (the endoplasmic reticulum, Golgi or endosomes), secreted from the cell, or inserted into most cellular membranes. Although most type I membrane-bound proteins have signal peptides, most type II and multi-spanning membrane-bound proteins are targeted to the secretory pathway by their first transmembrane domain, which biochemically resembles a signal sequence except that it is not cleaved. They are a kind of target peptide.

  1. ^ Kapp, Katja; Schrempf, Sabrina; Lemberg, Marius K.; Dobberstein, Bernhard (2013-01-01). Post-Targeting Functions of Signal Peptides. Landes Bioscience.
  2. ^ Owji, Hajar; Nezafat, Navid; Negahdaripour, Manica; Hajiebrahimi, Ali; Ghasemi, Younes (August 2018). "A comprehensive review of signal peptides: Structure, roles, and applications". European Journal of Cell Biology. 97 (6): 422–441. doi:10.1016/j.ejcb.2018.06.003. PMID 29958716. S2CID 49612506.
  3. ^ Blobel G, Dobberstein B (December 1975). "Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma". The Journal of Cell Biology. 67 (3): 835–51. doi:10.1083/jcb.67.3.835. PMC 2111658. PMID 811671.