Silene is a genus of plants.
Silene may also refer to:
- Silenes, chemical compounds containing a Si=Si moiety
- Silenes (Si=C), chemical compounds containing a Si=C moiety
- Silene, a Silenus-like figure in decorative art
- Silene, the location of the story of Saint George and the Dragon
- Silene, Skrudaliena Parish [lv], a village in Skrudaliena Parish, Latvia
- Silene, Saliena Parish [lv], a village in Saliena Parish, Latvia
- Silenė [lv], one of the lands of the historical Semigallia, Latvia