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 SimThyr 3.1 on openSUSE 11 | |
| Original author(s) | Johannes W. Dietrich, Ulla Mitzdorf, Renate Pickardt, Rudolf Hoermann, John E. M. Midgley |
|---|---|
| Developer(s) | Ruhr University Bochum |
| Initial release | 2002 |
| Stable release | 4.0.6
/ April 23, 2022 |
| Repository | |
| Written in | Pascal and Object Pascal |
| Operating system | macOS, Windows and Linux |
| Platform | PowerPC, IA-32, x86-64 and ARM, m68k (legacy versions only) |
| Available in | British English, German (SimThyr 2.0 or older only) |
| Type | Free scientific application software for physiological simulations |
| License | BSD-style |
| Website | simthyr |
SimThyr is a free continuous dynamic simulation program for the pituitary-thyroid feedback control system.[1] The open-source program is based on a nonlinear model of thyroid homeostasis.[2][3][4] In addition to simulations in the time domain the software supports various methods of sensitivity analysis. Its simulation engine is multi-threaded and supports multiple processor cores. SimThyr provides a GUI, which allows for visualising time series, modifying constant structure parameters of the feedback loop (e.g. for simulation of certain diseases), storing parameter sets as XML files (referred to as "scenarios" in the software) and exporting results of simulations in various formats that are suitable for statistical software. SimThyr is intended for both educational purposes and in-silico research.[4][5]
- ^ Dietrich, JW; Landgrafe, G; Fotiadou, EH (2012). "TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis". Journal of Thyroid Research. 2012: 351864. doi:10.1155/2012/351864. PMC 3544290. PMID 23365787.
- ^ Hoermann, R; Midgley, JE; Larisch, R; Dietrich, JW (2015). "Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment". Frontiers in Endocrinology. 6: 177. doi:10.3389/fendo.2015.00177. PMC 4653296. PMID 26635726.
- ^ Berberich, Julian (13 September 2018). "Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Matlab/Simulink Files for Simulation and Sensitivity Analysis". doi:10.5281/zenodo.1415331.
{{cite journal}}: Cite journal requires|journal=(help) - ^ a b Dietrich, Johannes W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis : Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin: Logos-Verlag. ISBN 978-3897228504.
- ^ Dietrich, Johannes W.; Midgley, John E. M.; Hoermann, Rudolf (2018). Homeostasis and Allostasis of Thyroid Function. Lausanne: Frontiers Media SA. ISBN 9782889455706.