Sintice or Sintike (Greek: Σιντική) was an ancient region and later district of the kingdom of Macedon.[1] It was located north of Bisaltia and Odomantike up to Messapio mount and west of Crestonia and South Paeonia to Strymon river and Orvilos mount. Its name is derived from the Sintians, a tribe which once inhabited the region. Beyond it, was stretching Medike which was held by the powerful Thracian tribe of Medi with which the Macedonians were in constant wars.