Sirtuin 1

SIRT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR
Identifiers
Aliases	SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
External IDs	OMIM: 604479; MGI: 2135607; HomoloGene: 56556; GeneCards: SIRT1; OMA:SIRT1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.3 Start 67,884,656 bp[1] End 67,918,390 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 63,154,784 bp[2] End 63,217,483 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence ventricular zone gonad testicle gastric mucosa right adrenal cortex left adrenal cortex white blood cell monocyte Top expressed in spermatocyte primitive streak superior cervical ganglion epiblast hair follicle Gonadal ridge ciliary body tail of embryo genital tubercle cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein domain specific binding core promoter sequence-specific DNA binding protein C-terminus binding keratin filament binding transcription factor binding metal ion binding HLH domain binding enzyme binding protein deacetylase activity histone binding protein binding NAD-dependent histone deacetylase activity NAD-dependent protein deacetylase activity histone deacetylase activity p53 binding mitogen-activated protein kinase binding deacetylase activity bHLH transcription factor binding NAD+ binding identical protein binding NAD+ ADP-ribosyltransferase activity hydrolase activity NAD-dependent histone deacetylase activity (H3-K9 specific) DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nuclear envelope rDNA heterochromatin chromatin silencing complex mitochondrion nucleus ESC/E(Z) complex nucleolus chromatin nucleoplasm PML body nuclear inner membrane cytosol Biological process cellular triglyceride homeostasis positive regulation of MHC class II biosynthetic process DNA synthesis involved in DNA repair positive regulation of protein phosphorylation positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway rhythmic process single strand break repair muscle organ development histone H3-K9 deacetylation negative regulation of cellular response to testosterone stimulus regulation of peroxisome proliferator activated receptor signaling pathway cellular response to DNA damage stimulus regulation of bile acid biosynthetic process DNA replication negative regulation of TOR signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of glucose metabolic process rDNA heterochromatin assembly negative regulation of DNA damage response, signal transduction by p53 class mediator DNA methylation-dependent heterochromatin assembly circadian rhythm positive regulation of cellular senescence spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage cellular response to ionizing radiation negative regulation of helicase activity cholesterol homeostasis response to leptin cellular response to hypoxia triglyceride mobilization negative regulation of prostaglandin biosynthetic process proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process peptidyl-lysine deacetylation negative regulation of fat cell differentiation negative regulation of peptidyl-lysine acetylation regulation of transcription, DNA-templated positive regulation of adaptive immune response stress-induced premature senescence negative regulation of androgen receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway response to oxidative stress negative regulation of DNA-binding transcription factor activity negative regulation of gene expression transcription, DNA-templated negative regulation of cAMP-dependent protein kinase activity pyrimidine dimer repair by nucleotide-excision repair response to insulin histone H3-K9 modification positive regulation of macroautophagy positive regulation of cholesterol efflux protein ubiquitination negative regulation of cell growth positive regulation of macrophage apoptotic process rRNA processing regulation of brown fat cell differentiation negative regulation of phosphorylation viral process DNA repair negative regulation of neuron death positive regulation of histone H3-K9 methylation negative regulation of histone H3-K14 acetylation negative regulation of protein kinase B signaling cell differentiation ovulation from ovarian follicle regulation of protein serine/threonine kinase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein ADP-ribosylation leptin-mediated signaling pathway negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization negative regulation of I-kappaB kinase/NF-kappaB signaling circadian regulation of gene expression protein deacetylation fatty acid homeostasis protein destabilization regulation of mitotic cell cycle positive regulation of cAMP-dependent protein kinase activity white fat cell differentiation positive regulation of insulin receptor signaling pathway negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity peptidyl-lysine acetylation response to hydrogen peroxide intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of histone H4-K16 acetylation positive regulation of endothelial cell proliferation regulation of smooth muscle cell apoptotic process behavioral response to starvation cellular glucose homeostasis cellular response to starvation cellular response to tumor necrosis factor positive regulation of DNA repair multicellular organism development regulation of cell population proliferation positive regulation of cell population proliferation regulation of endodeoxyribonuclease activity regulation of cellular response to heat positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway UV-damage excision repair histone deacetylation positive regulation of transcription by RNA polymerase II angiogenesis macrophage cytokine production regulation of lipid storage positive regulation of adipose tissue development macrophage differentiation transcription by RNA polymerase II positive regulation of smooth muscle cell differentiation negative regulation of histone H3-K9 trimethylation positive regulation of apoptotic process cellular response to hydrogen peroxide histone H3 deacetylation negative regulation of protein acetylation regulation of apoptotic process cellular response to leukemia inhibitory factor positive regulation of angiogenesis transforming growth factor beta receptor signaling pathway positive regulation of blood vessel endothelial cell migration negative regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23411 93759 Ensembl ENSG00000096717 ENSMUSG00000020063 UniProt Q96EB6 Q923E4 RefSeq (mRNA) NM_001142498 NM_001314049 NM_012238 NM_001159589 NM_001159590 NM_019812 RefSeq (protein) NP_001135970 NP_001300978 NP_036370 NP_001153061 NP_062786 Location (UCSC) Chr 10: 67.88 – 67.92 Mb Chr 10: 63.15 – 63.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.^[5][6][7]

SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2. SIRT1 is an enzyme located primarily in the cell nucleus that deacetylates transcription factors that contribute to cellular regulation (reaction to stressors, longevity).^[8][9]