Sirtuin 5

SIRT5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B4Y, 2NYR, 3RIG, 3RIY, 4F4U, 4F56, 4G1C, 4HDA, 5BWL
Identifiers
Aliases	SIRT5, SIR2L5, sirtuin 5
External IDs	OMIM: 604483; MGI: 1915596; HomoloGene: 40825; GeneCards: SIRT5; OMA:SIRT5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p23 Start 13,574,529 bp[1] End 13,615,158 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A4 Start 43,518,972 bp[2] End 43,548,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm apex of heart left ventricle buccal mucosa cell Skeletal muscle tissue of rectus abdominis right lobe of liver body of tongue muscle of thigh tendon of biceps brachii biceps brachii Top expressed in interventricular septum morula extraocular muscle myocardium of ventricle left lobe of liver soleus muscle hand digastric muscle tibialis anterior muscle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity metal ion binding NAD+ ADP-ribosyltransferase activity NAD+ binding protein-succinyllysine desuccinylase activity protein-malonyllysine demalonylase activity zinc ion binding NAD-dependent protein deacetylase activity protein-glutaryllysine deglutarylase activity Cellular component cytoplasm mitochondrial intermembrane space mitochondrion nucleus cytosol mitochondrial matrix mitochondrial inner membrane Biological process protein deacetylation negative regulation of cardiac muscle cell apoptotic process response to nutrient levels protein ADP-ribosylation negative regulation of reactive oxygen species metabolic process peptidyl-lysine deglutarylation mitochondrion organization regulation of ketone biosynthetic process protein demalonylation peptidyl-lysine demalonylation protein desuccinylation peptidyl-lysine desuccinylation protein deglutarylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23408 68346 Ensembl ENSG00000124523 ENSMUSG00000054021 UniProt Q9NXA8 Q8K2C6 RefSeq (mRNA) NM_001193267 NM_001242827 NM_012241 NM_031244 NM_178848 RefSeq (protein) NP_001180196 NP_001229756 NP_036373 NP_112534 NP_001363727 NP_001363728 NP_001363729 NP_001363730 NP_001363731 NP_001363732 NP_001363733 NP_001363734 NP_001363735 NP_001363736 NP_001363737 NP_001363738 NP_001363739 NP_001363740 NP_001363741 NP_001363742 NP_001363743 NP_001363744 NP_849179 Location (UCSC) Chr 6: 13.57 – 13.62 Mb Chr 13: 43.52 – 43.55 Mb PubMed search [3] [4]
Wikidata
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Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the orthologous Sirt5 gene.^[5]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and belong to the class III of the [histone deacetylase] superfamily, and are dependent on NAD+ as co-factor of enzymatic activities. SIRT5 is one of the three sirtuins localized primarily to the mitochondrion.