In molecular biology, Six3OS1 is a long non-coding RNA. It was originally identified in the murine embryonic and postnatal retina.[1] It is located in the distal promoter region of the gene encoding Six3, a homeodomain transcription factor. It regulates the activity of Six3 in the developing mouse retina, by binding to transcriptional co-regulators of Six3 and to histone modification enzymes and acting as a transcriptional scaffold.[2]
- ^ Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, et al. (2005). "Natural antisense transcripts associated with genes involved in eye development". Hum Mol Genet. 14 (7): 913–923. doi:10.1093/hmg/ddi084. PMID 15703187.
- ^ Rapicavoli NA, Poth EM, Zhu H, Blackshaw S (2011). "The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity". Neural Dev. 6: 32. doi:10.1186/1749-8104-6-32. PMC 3191369. PMID 21936910.