Sodium fluoride

Sodium fluoride
Sodium fluoride
Sample of sodium fluoride, AR grade
Names
Pronunciation /ˌsdiəm ˈflʊərd/[1]
IUPAC name
Sodium fluoride
Other names
Florocid
Identifiers
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.028.789 Edit this at Wikidata
EC Number
  • 231-667-8
KEGG
RTECS number
  • WB0350000
UNII
UN number 1690
  • InChI=1S/FH.Na/h1H;/q;+1/p-1 checkY
    Key: PUZPDOWCWNUUKD-UHFFFAOYSA-M checkY
  • InChI=1/FH.Na/h1H;/q;+1/p-1
    Key: PUZPDOWCWNUUKD-REWHXWOFAH
Properties
NaF
Molar mass 41.988173 g/mol
Appearance White to greenish solid
Odor odorless
Density 2.558 g/cm3
Melting point 993 °C (1,819 °F; 1,266 K)
Boiling point 1,704 °C (3,099 °F; 1,977 K)
36.4 g/L (0 °C);
40.4 g/L (20 °C);
50.5 g/L (100 °C)[2]
Solubility slightly soluble in HF, ammonia
negligible in alcohol, acetone, SO2, dimethylformamide
Vapor pressure 1 mmHg @ 1077 °C[3]
Acidity (pKa) 3,20 (weak base, see HF)
−16.4·10−6 cm3/mol
1.3252
Structure
Cubic
a = 462 pm
Octahedral
Thermochemistry
46.82 J/(mol K)
51.3 J/(mol K)
-573.6 kJ/mol
-543.3 kJ/mol
Pharmacology
A01AA01 (WHO) A12CD01 (WHO),
V09IX06 (WHO) (18F)
Hazards
GHS labelling:
Acute Toxicity GHS07: Exclamation mark GHS08: Health hazard
Danger
H301, H315, H319, H335[4]
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
3
0
0
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
52–130 mg/kg (oral in rats, mice, rabbits)[6]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 2.5 mg/m3[5]
REL (Recommended)
TWA 2.5 mg/m3[5]
IDLH (Immediate danger)
250 mg/m3 (as F)[5]
Safety data sheet (SDS) [4]
Related compounds
Other anions
Sodium chloride
Sodium bromide
Sodium iodide
Sodium astatide
Other cations
Lithium fluoride
Potassium fluoride
Rubidium fluoride
Caesium fluoride
Francium fluoride
Related compounds
TASF reagent
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium fluoride (NaF) is an inorganic compound with the formula NaF. It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose. In 2021, it was the 291st most commonly prescribed medication in the United States, with more than 600,000 prescriptions.[7][8] It is also used in metallurgy and in medical imaging.

  1. ^ Wells, John C. (2008), Longman Pronunciation Dictionary (3rd ed.), Longman, pp. 313 and 755, ISBN 978-1-4058-8118-0. According to this source, an alternative pronunciation of the second word is /ˈflɔːrd/ and, in the UK, also /ˈflərd/.
  2. ^ Haynes, William M., ed. (2011). CRC Handbook of Chemistry and Physics (92nd ed.). CRC Press. p. 5.194. ISBN 978-1-4398-5511-9.
  3. ^ Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1–3 New York, NY: John Wiley & Sons Inc., 1999., p. 3248
  4. ^ a b Sigma-Aldrich Co., Sodium Fluoride.
  5. ^ a b c NIOSH Pocket Guide to Chemical Hazards. "#0563". National Institute for Occupational Safety and Health (NIOSH).
  6. ^ Martel, B.; Cassidy, K. (2004), Chemical Risk Analysis: A Practical Handbook, Butterworth–Heinemann, p. 363, ISBN 978-1-903996-65-2
  7. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  8. ^ "Sodium Fluoride – Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.