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Trade names | Pentostam, Stiboson, others[1] |
AHFS/Drugs.com | International Drug Names |
Routes of administration | intravenous, intramusclar[2] |
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ECHA InfoCard | 100.170.909 |
Chemical and physical data | |
Formula | C12H38Na3O26Sb2 |
Molar mass | 910.899 g·mol−1 |
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Sodium stibogluconate, sold under the brand name Pentostam among others, is a medication used to treat leishmaniasis.[3] This includes leishmaniasis of the cutaneous, visceral, and mucosal types.[4] Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended due to issues with resistance.[2][5] It is given by injection.[6]
Side effects are common and include loss of appetite, nausea, muscle pains, headache, and feeling tired.[2][5] Serious side effect may include an irregular heartbeat or pancreatitis.[5] Sodium stibogluconate is less safe than some other options during pregnancy.[2] It is not believed to result in any problems if used during breastfeeding.[7] Sodium stibogluconate is in the pentavalent antimonials class of medication.[5]
Sodium stibogluconate has been studied as early as 1937 and has been in medical use since the 1940s.[8][9] It is on the World Health Organization's List of Essential Medicines.[10] In the United States, it is available from the Centers for Disease Control.[3]