Somatostatin receptor 4

SSTR4
Identifiers
Aliases	SSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDs	OMIM: 182454; MGI: 105372; HomoloGene: 20286; GeneCards: SSTR4; OMA:SSTR4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,039,237 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	148,238,687 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; cingulate gyrus; ; right frontal lobe; ; anterior cingulate cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; Brodmann area 9; ; amygdala; ; islet of Langerhans; ; hippocampus proper;
	Top expressed in
	intestinal villus; ; Ileal epithelium; ; perirhinal cortex; ; entorhinal cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; superior frontal gyrus; ; granulocyte; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide binding; G protein-coupled receptor activity; signal transducer activity; somatostatin receptor activity; peptide binding;
Cellular component	cytoplasm; integral component of membrane; neuron projection; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; forebrain development; cellular response to glucocorticoid stimulus; cell migration; arachidonic acid metabolic process; positive regulation of MAPK cascade; negative regulation of cell population proliferation; signal transduction; somatostatin signaling pathway; chemical synaptic transmission; positive regulation of ERK1 and ERK2 cascade; positive regulation of arachidonic acid secretion; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6754
	20608
	ENSG00000132671
	ENSMUSG00000037014
	P31391
	P49660
	NM_001052
	NM_009219
	NP_001043
	NP_033245
	Wikidata
View/Edit Human	View/Edit Mouse

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132671 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037014 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schüle R (May 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proceedings of the National Academy of Sciences of the United States of America. 90 (9): 4196–200. Bibcode:1993PNAS...90.4196R. doi:10.1073/pnas.90.9.4196. PMC 46473. PMID 8483934.
^ "Entrez Gene: SSTR4 somatostatin receptor 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132671 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037014 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8483934-5] Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schüle R (May 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proceedings of the National Academy of Sciences of the United States of America. 90 (9): 4196–200. Bibcode:1993PNAS...90.4196R. doi:10.1073/pnas.90.9.4196. PMC 46473. PMID 8483934.

[entrez-6] "Entrez Gene: SSTR4 somatostatin receptor 4".

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