Sophia Gurieli (Georgian: სოფიო გურიელი, romanized: sopio gurieli), née Tsulukidze (წულუკიძე) (died 7 September 1829) was a princess consort of Guria, in southwestern Georgia, as the wife of Mamia V Gurieli. She served as regent for her underage son David Gurieli in 1826-1829. In 1829 she resisted the Russian encroachment on Gurian self-rule and sided with the Ottoman Empire, but failed and had to flee to Trebizond, where she died the same year.