Sorbitol dehydrogenase

sorbitol dehydrogenase
Sorbitol dehydrogenase tetramer, Human
Identifiers
Symbol	SORD
NCBI gene	6652
HGNC	11184
OMIM	182500
RefSeq	NM_003104
UniProt	Q00796
Other data
EC number	1.1.1.14
Locus	Chr. 15 q15-q21.1
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Sorbitol dehydrogenase (or SDH) is a cytosolic enzyme. In humans this protein is encoded by the SORD gene.^[1]

Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose.^[2] Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP. Sorbitol dehydrogenase uses NAD⁺ as a cofactor; its reaction is sorbitol + NAD⁺ → fructose + NADH + H⁺. A zinc ion is also involved in catalysis. Organs that use it most frequently include the liver and seminal vesicle; it is found in various organisms from bacteria to humans. A secondary use is the metabolism of dietary sorbitol, though sorbitol is known not to be absorbed as well in the intestine as its related compounds glucose and fructose, and is usually found in quite small amounts in the diet (except when used as an artificial sweetener).