State highway in South Carolina
South Carolina Highway 72 (SC 72) is a 124.860-mile (200.943 km) state highway, traversing interior portions of the South Carolina Piedmont region. This route is part of a multi two-state route 72 that begins at Athens, Georgia and ends at Rock Hill, South Carolina. The route connects many smaller communities outside major metropolitan areas and is roughly parallel with Interstate 85 (I-85) to the north and I-20 and I-77 to the south and east. The route shares the longest concurrency in the state with SC 121, from Whitmire to Rock Hill.