| Sport | Rugby Union |
|---|---|
| Instituted | 2000 |
| Ceased | 2002 |
| Country |  England |
| Holders | Holmes Chapel (1st title) (2000–01) (promoted to South Lancs/Cheshire 4) |
| Most titles | Holmes Chapel, Oswestry (1 title) |
| Website | clubs.rfu.com |
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South Lancs/Cheshire 5 was a regional English rugby union league for teams from the South Lancashire, Cheshire and Manchester region and was at the tenth tier of national competition. Promoted teams moved up to South Lancs/Cheshire 4 and as the basement division in the local region there was no relegation. Dwindling numbers of teams led to the division being cancelled at the end of the 2001-02 season and teams would either move up to South Lancs/Cheshire 4 or drop out of the league altogether.